Partho Ghosh, Ph.D., is Professor of Chemistry & Biochemistry at the University of California, San Diego. He received his BS in Molecular Biophysics & Biochemistry from Yale University, where he carried out research with Dr. Peter Moore on the structure and dynamics of the 5S ribosomal RNA. Dr. Ghosh then moved to the University of California, San Francisco to carry out doctoral research with Dr. Robert Stroud, and worked on the X-ray crystallographic structure and mechanism of action of ion channels and pore-forming toxins. After graduate school, Dr. Ghosh moved to Harvard University to carry out postdoctoral research on the structural biology of the immune response with the late Dr. Don Wiley.
He and his group are studying how molecular interactions between microbial pathogens and hosts lead to infectious disease. To find ways to intervene against such diseases, the Ghosh lab is investigating how bacterial pathogen proteins interact with their mammalian targets using a combination of structural biology (i.e., X-ray crystallography, NMR, and electron microscopy), biochemistry, cell biology, and reverse genetics. The Ghosh lab is focusing its efforts on group A Streptococcus, diversity-generating retroelements, Enterococcus, and the Yersinia type III secretion system.
Abstracts this author is presenting: