Dr. McIver is Professor of Cell Biology & Molecular Genetics in the Maryland Pathogen Research Institute (MPRI) at the University of Maryland, College Park in the United States. His research focuses on the molecular mechanisms of pathogenesis of the Gram-positive pathogen Streptococcus pyogenes (Group A Streptococcus, GAS), a major contributor to the clinical burden of infectious disease around the world. Major areas of interest involve studying the adaptation of the human-restricted GAS to various niches in its host and understanding the pathophysiology relevant to GAS disease. In addition, Dr. McIver has characterized coordinate virulence gene regulatory networks and the signal transduction pathways involved, including the PRD-containing Virulence Regulators Mga and 2-component systems such as TrxSR. The McIver lab applies forward functional genomic screens (Tn-seq) combined with transcriptomics (RNA-seq), proteomics (LCMSMS), and animal models, to help answer these important questions. He received his Ph.D. from the University of Tennessee Health Sciences Center in 1994 with Dr. Dennis Ohman, was a postdoctoral fellow with Dr. June Scott at Emory University School of Medicine, and spent 7 years in the Dept. of Microbiology & Immunology at University of Texas Southwestern Medical Center in Dallas before moving his research group to Maryland in 2006.
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