Tuesday, 17th October 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases 2017

• Streptococcal Just So stories: or, what we can learn from genomics - Shiranee Sriskandan

Proudly Sponsored by

• Treatment of Group A Strep beyond antibiotics - Annelies Zinkernagel
• Immunity after Group A Streptococcal infections: Beyond emm-type specific response - Pierre Smeesters
• Mechanisms of Blood-Brain Barrier Penetration by Group B Streptococcus - Kelly Doran

• Population genomics of Group A Streptococci: Application to global vaccine design - Mark Davies
• Global Burden of Rheumatic Heart Disease - David Watkins
• Group A Streptococcus Vaccine Development: An Urgent Global Health Need - Jerome Kim
• Streptococcal surface glycans at the host-pathogen interface - Nina M van Sorge
• The Endgame for Rheumatic Heart Disease in Australia - Jonathan Carapetis

• Where are we at with treatment and control of group A streptococcal impetigo? - Asha Bowen
• The role of Streptococcus pyogenes and other beta-hemolytic streptococci in erysipelas and cellulitis. - Trond Bruun
• The Novel Group A Streptococcus antigen SpnA combined with Bead‑based Immunoassay Technology improves Streptococcal Serology for the Diagnosis of Acute Rheumatic Fever - Nicole Moreland
• Feasibility and safety of mass co-administration of azithromycin and ivermectin to control trachoma and scabies: the AIM study - Lucia Romani
• A serological evaluation of the host immune response during Necrotizing Soft Tissue Infections caused by Streptococcus pyogenes - Anshu Babbar
• Rheumatic Heart Disease: Morbidity and Long Term Sequelae, Auckland Hospital, New Zealand 2012 - Kate Jardine

• Not a coiled coil: structural characterization of the hypervariable region of M3 and its role in collagen binding and biofilm - Ulrich Schwarz-Linek
• Band 3 Protein Activation by Group A Streptococcus Streptolysin S Initiates Erythrocyte Hemolysis - Shaun Lee
• Innovative Strategies for Antivirulence Therapeutics to Neutralize Streptolysin O-mediated Cytotoxicity - Tamara Escajadillo
• PmtA is a PerR-regulated ferrous iron efflux system of group A Streptococcus - Andrew G Turner
• Complement independent activity of C5a peptidase contributes to Streptococcal pathogenesis and impairs the host innate immune response - Nicola N Lynskey
• Characterization of a novel tyrosine kinase and tyrosine phosphorylation in Streptococcus pyogenes - Vijay Pancholi

• Group B Streptococcus in the urinary tract: infectious mechanisms and elements of pathogenesis - Glen Ulett
• Group B Streptococcus in in sub-Saharan Africa - Anna Seale
• Genomic investigation of the rise in incidence of Group B Streptococcus neonatal invasive disease in the Netherlands - Dorota Jamrozy
• Dual activities of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing - Satoshi Uchiyama
• The two-component system response regulator LytR influences Group B Streptococcal colonization and disease - Liwen Deng
• Do the benefits of universal group B Streptococcus (GBS) screening to prevent early-onset GBS disease (EOGBS) outweigh the harms? An evidence review for the UK National Screening Committee (NSC) - Farah Seedat

• Host genetic susceptibility to rheumatic heart disease - Kathryn Auckland
• The AFROStrep Registry antad Biorepositry for Streptococcus pyogenes:  the first year in South Africa - Mark Engel
• Measuring adherence to secondary prophylaxis for acute rheumatic fever and rheumatic heart disease: which indicators predict ARF recurrences and can be easily monitored? - Jessica de Dassel
• The New Zealand familial echo study: High prevalence of Rheumatic Heart Disease in siblings of Acute Rheumatic Fever cases supports active case finding in family members - Rachel Webb
• Is rheumatic heart disease screening by non-expert operators feasible and accurate? Lessons from the Fiji studies. - Daniel Engelman
•   Robust Evidence Finally Available for Prevention of First Presentation Acute Rheumatic Fever in a Community Setting :   a school based intervention. - Diana Lennon

• Genetic basis of serotype-specific phenotypic variation in the group A Streptococcus   - Paul Sumby
• The utility of Whole Genome Sequencing in Group A Streptococcus outbreaks in England – a perspective from the reference laboratory - Juliana Coelho
• Recombination-related remodeling in the group A streptococcal genome - Claire E Turner
• What comes after M Conservation of the core Mga regulon of Group A streptococcus - Hannah RC Frost
• Whole-genome sequencing analysis of group A streptococcal isolates associated with an invasive disease outbreak in Alaska - Karen Rudolph
• Population genomic epidemiology of Streptococcus pyogenes in the Faroe Islands - Stephen B Beres

• Genetics, Genomics and the role of group G streptococcus in human disease - David McMillan
• Serum antibodies to DRSG protein from Streptococcus dysgalactiae subsp equisimilis increase the risk for chronic kidney diseases: parallels with IgA nephropathy. - Kadaba (Sri) S Sriprakash
• Novel genetic determinants of Streptococcus dysgalactiae subspecies equisimilis  - Alexander V Dmitriev
• Four consecutive multicenter external quality assessments to assess the quality of molecular amplification methods for the detection of vancomycin resistant enterococci   - Margareta Ieven
• Beneficial health outcomes following use of probiotic Streptococcus salivarius K12 - John Hale
• Atypical Streptococcus dysgalactiae subspecies equisimilis (SDSE) in England in Wales – a perspective from the reference laboratory - Juliana Coelho

Includes drinks and canapes 

• Expression of the Group B Streptococcus cyl operon in Lactococcus lactis confers hemolysin production - Blair Armistead
• Dendritic cells are susceptible to death in response to hyperpigmented Group B Streptococcus - Michelle M Coleman
• Vaginal viridans streptococci and Lactobacilli have synergistic inhibiting effect on group B streptococci - Eva Grahn Håkansson
• Serotyping and Antibiotic Susceptibility Of Invasive Streptococcus Agalactia (GBS) In Egypt - Sawsan El Tayeb
• Erythritol, a polyol (sugar alcohol), enhances Group B Streptococcus virulence - Maram J Hulbah
• Late onset Group B streptococcal infections in the neonatal unit - a genomic re-evaluation of causality - Elita Jauneikaite
• Quantifying the burden of Group B Streptecoccus as a cause of surgical site infection in England - Theresa Lamagni
• Prevalence and characteristics of group B streptococcus colonization in HIV-infected pregnant women in Belgium   - Pierrette Melin
• Update of the characteristics of Group B Streptococci (GBS) colonizing pregnant women in Belgium: capsular-type distribution, pili characterization, antimicrobial susceptibility profile and Multiple Locus Sequence Types. - Pierrette Melin
• Evolution of rate and genotypes of resistance to macrolide/lincosamide among invasive Group B Streptococcus (GBS): Development of a multiplex PCR tool for simultaneous detection of ErmB, ErmTr, MefA and LsaC resistance genes.   - Pierrette Melin
• Prevalence and capsular-polysaccharide type distribution of colonizing group B streptococci (GBS) isolated from recto-vaginal samples in pregnant women in Hanoï, Vietnam - Pierrette Melin
• Susceptibility Testing of Streptococcus agalactiae isolates from pregnant women to indigenous and conventional antimicrobials - Sylvester Rodgers SR Moyo
• Bacterial load and bacterial molecular markers associated with neonatal Group B Streptococcus (GBS): A systematic review - Farah Seedat
• Adverse outcomes in women and children who have received intrapartum antibiotic prophylaxis (IAP) treatment: A systematic review - Farah Seedat
• A comparison in the international trends of neonatal group B Streptococcus (GBS) under different GBS prevention strategies - Farah Seedat
• The role of Streptococcus agalactiae CovR in urinary tract infection  - Matthew J Sullivan
• Isolation and Partial Biochemistry Characterization of Surface Immunological Protein from a Chilean-isolated Bacterial Strain of Group B Streptococcus - Abel E Vasquez
• The Streptococcus suis serotype 2 lipoproteins, but not the lipoteichoic acid, are important activators of the innate immune response - Marcelo Gottschalk
• The prevalence of Streptococcus suis in tiet canh, a traditional raw pig blood dish in Vietnam - Ha Huynh
• Comparison of Streptococcus suis in pig farms and the swine oral microbiota between Japan and Vietnam - Hyunjung Kim
• Emerging high virulent strain Streptococcus suis serotype 9 from brain meningitis epidemic outbroken in piglets - Zihao Pan
• STK regulating cell division by modulating DivIVA phosphorylation in Streptococcus suis - Xiuzhen Pan
• Antimicrobial susceptibility and common virulence genotype of Streptoccocus suis serotype 2 isolate from patient in Cambodia, Laos and Viet Nam - Chieu Tran
• Immunological response of Streptococcus suis infected patients admitted to Hospital of Tropical Diseases in Southern of VietNam (2015-2016)   - Ngoc Vuong
• The differential ribosome profiling approach presents the complexity of Streptococcus suis translational landscape - Zongfu Wu
• Insight into the specific pathogenicity islands and Serine-Rich Repeat Protein SssP1 in the Streptococcus suis novel serotype Chz - Huochun Yao
• Defining the ABC of gene essentiality in streptococci - Amelia Charbonneau
• Streptococcus pneumoniae Ccs4 involved in penetration across blood-brain barrier and virulence in meningitis - Yujiro Hirose
• Group G streptococcus induces autoimmune mediated carditis in the Lewis rat model of Rheumatic Heart Disease - Suchandan Sikder
• Functional Analysis of Streptococcal Virulence Factors - Kar Yan Soh
• Characterization of a novel plasmid discovered in a clinical isolate of Streptococcus anginosus subsp. anginosus - Atsushi Tabata
• Echocardiography studies of mini pigs immunized with repeated doses of StreptInCor a candidate vaccine to prevent S. pyogenes infections as a safety control - Raquel Alencar
• PilVax: a novel peptide carrier for the development of vaccines against tuberculosis - Samuel D Blanchett
• TeeVax – a multivalent T-antigen-based vaccine against group A streptococcus - Jacelyn Loh
• Toxicity and skin sensitization assays as preclinical evaluations of StreptInCor a candidate vaccine to prevent S. pyogenes infections - Edilberto Postol
• Using structural biology to inform the design of T-antigen based vaccines for Group A Streptococcus - Jeremy Raynes
• Distribution of collagen binding PARF Motifs in M Proteins of Group A, C and G Streptococcal Strains from North India - Vivek Sagar
• PilVax – a novel peptide antigen delivery strategy for vaccine development - Catherine Tsai
• Liposomal peptide vaccine delivery system induces protective humoral and cellular immune responses against group A streptococcus in the upper respiratory tract - Mehfuz Zaman
• Genome-wide association study of susceptibility to rheumatic heart disease in South Asians: Preliminary results - Kathryn Auckland
• Demonstration of Antibody Dependent Enhancement (ADE) like phenomenon in cases of pyoderma & pharyngitis caused by Group A Streptococci (GAS) & Streptococcus dysgalactiae subspecies equisimilis (SDSE) - Mohan Karmarkar
• Streptococcal Inhibitor of Complement (SIC) was detected in mesangium and glomerular capillary walls in kidney biopsies of patients having glomerular diseases - Mohan Karmarkar
• A Systematic Analysis of Immunoglobulin and Complement Pathways in Patients with Acute Rheumatic Fever - Nicole Moreland
• Proinflammatory, adhesion and cytoskeletal gene expression and their  promoter methylation in the mitral valves of rheumatic heart disease patients - Mukul Rastogi
• Development of a high throughput HL-60 opsonophagocytic killing (OPK) assay for group A streptococci - Sanaz Salehi
• Development of surrogate of protection assays for group a streptococcus - H. Alexandra Shaw
• The GAS “Tetradigm” of pharyngeal symptoms and immune responses: Implications for ARF? - Robert R Tanz
• Identifying Autoantibody Targets as New Biomarkers for Acute Rheumatic Fever using Mass Spectrometry and High Content Protein Arrays - Mei Lin Tay
• Defining “strain”: Development of an MLST scheme based on surface protein genes for group A streptococci - Debra E Bessen
• Genomic sequencing analysis of emm66 group A streptococcus (GAS) isolates associated with an ongoing outbreak of invasive infection in England and Wales from January 2016 - Laura Bubba
• An occurrence of ICE-emm12 element containing tetM and ermB resistance genes among Russian and Vietnamese Streptococcus pyogenes strains - Alexander V Dmitriev
• Genetic variants associated with Rheumatic Fever and Rheumatic Heart Disease: A HuGENet^TM systematic review and meta-analysis - Babu Muhamed
• An in silico evaluation of the genomic features upstream of Streptococcus pyogenes two-component system proteins and relationships with disease - Sean J Buckley
• Getting to know you: what makes an emm75 GAS human challenge strain stick? - Kristy Azzopardi
• Caveolin-1 restricts group A Streptococcus invasion into non-phagocytic host cells - Timothy Barnett
• Relative contributions of M- and FCT-region cell surface proteins to fitness and virulence of a classical group A streptococcal skin strain - Debra E Bessen
• Role of streptokinase in early stages of group A streptococcus skin infection - Debra E Bessen
• Sensor protein CovS regulates Rgg-LacD.1 system through modulating the phosphorylation level of response regulator CovR in group A Streptococcus - Chuan Chiang-Ni
• A novel interaction between C4BP and the Enn protein of Group A streptococcus - Hannah RC Frost
• Selection of M protein deficient Streptococcus pyogenes: mechanisms and insights - Kristin K Huse
• RocA is a pseudokinase that enhances the virulence-regulating activity of the CovR/S two-component system in the group A Streptococcus - Ira Jain
• Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity - Adrina Hema Jethanand-Khemlani
• Roles of Gal-3 and Gal-8 in Group A streptococcus infection - Yee-Shin Lin
• Don't stain! show live bacteria - Alice Mitchell
• EGFR-mediated post-translational modification of group A Streptococcus (GAS) serine/threonine phosphatase (SP-STP) and protein tyrosine phosphatase (SP-PTP) - Vijay Pancholi
• Eukaryote-like serine/threonine kinase (StkP)- and phosphatase (PhpP)-mediated modulation of the S. pneumoniae virulence - Preeti Pancholi
• Context-specific effects of the chemokine cleaving enzyme SpyCEP on neutrophil clearance of S. pyogenes - Max Pearson
• Early Extracellular Lymphatic Dissemination of Streptococcus pyogenes: Prevalence and Implications for Pathogenesis - Matthew K Siggins
• Lactobacilli can be used as oral probiotics for upper respiratory tract infections and can together with commensal viridans streptococci eradicate Group A Streptococci - Charlotte IM Simark-Mattsson
• The Group A Streptococcus serotype M2 pilus plays a role in host cell adhesion and immune evasion. - Catherine Tsai
• Central inflame induced by group A streptococcal infection is attenuated by blocking peripheral TNF - Pei-Jane Tsai
• Structural and functional studies of a transcriptional regulator Rgg in group A Streptococcus - Shu-Ying Wang
• Alteration of polymorphonuclear leukocyte regulated cell death by Group A Streptococcus contributes towards inflammation - Jonathan G Williams
• The NAD-glycohydrolase mediates the multiplication of Group A Streptococcus in endothelial cells - Jiunn Jong Wu
• Whole metagenome profiling confirms the molecular link between Sarcoptes scabiei and impetigo - Charlotte Bernigaud
• Differences in SpeB protease activity among group A streptococci associated with superficial, invasive, and autoimmune disease - Debra Bessen
• GAS and scabies - New insights into the pathogenic mechanisms between scabies and associated secondary streptococcal skin infections. - Katja Fischer
• Is dried blood spot (DBS) a real-world alternative to serum sampling for the collection of blood penicillin levels? - Robert M Hand
• Global quality of benzathine penicillin G (BPG) – is potency an issue? - Robert M Hand
• Streptococcus is still a common cause of diabetic foot infection, a retrospective observational study in a multidisciplinary diabetic foot unit (MDFU) inpatient cohort - Robert M Hand
• Role of angiopoietin-1 and angiopoietin-2 during group A streptococcal infections: clinical and human endothelial cell studies - Ching-Chuan Liu
• Group A Streptococcus pharyngitis and pharyngeal carriage: A systematic review - Jane R Oliver
• Long-Term Effect of Mass Drug Administration For Scabies Control In Fiji: Experience From The SHIFT trial - Lucia Romani
• Group A streptococcal vaccine diplomacy – opportunities for Oceanic leadership - Rosemary Wyber
• Addressing shortcomings in International Classification of Diseases (ICD) codes for monitoring the burden of rheumatic heart disease (RHD): flogging a dead horse? - Marian Abouzeid
• Rheumatic heart disease in the Western Pacific region - Marian Abouzeid
• Morbidity and mortality following valve replacement surgery for rheumatic heart disease in Fiji - Samantha Colquhoun
• Secondary antibiotic prophylaxis for latent rheumatic heart disease: current state and opportunities for improvement - Daniel Engelman
• The natural history of screening-detected rheumatic heart disease: clinical and echocardiographic outcomes in Fiji - Daniel Engelman
• Obesity and subsequent weight gain in children hospitalised with acute rheumatic fever - Jodie Hayward
• Cost of tertiary care treatment for Rheumatic Heart Disease in India - Jyoti Dixit
• Innovations In Delivery Of Secondary Prophylaxis Treatment For People Living With RHD In Fiji Islands   - Elizabeth Kennedy
• Reducing pain associated with intramuscular (IM) Benzathine Penicillin in the rheumatic fever population – Using lignocaine - Linda LL Legge
• The duration of rheumatic fever prophylaxis in adults in greater Auckland, New Zealand. - Briana Northey
• Maori and Pacific whanau experiences of recurrent rheumatic fever and unexpected rheumatic heart disease in New Zealand - Briar Peat
• The natural & unnatural history of acute rheumatic fever in the modern era. - Briar Peat
• Rheumatic fever assessment of adherence to secondary prophylaxis and factors associated with poor adherence in Tavua hospital Fiji - Ashnita Prasad
• The benzathine penicillin G (BPG) reformulation preferences study - towards a new penicillin for rheumatic fever and rheumatic heart disease - Dianne Sika-Paotonu
• Invasive group A Streptococcal disease surveillance - Ciara Baker
• Effect of influenza activity on the incidence and severity of invasive group A streptococcal disease: a retrospective study in England, 2008-2016. - Laura Bubba
• A mathematical framework for understanding the role of asymptomatic carriers in the transmission of infectious diseases - Rebecca Chisholm
• Low prevalence rates for group A β-Haemolytic Streptococcal Carriage in Africa: A Cross-Sectional Study and Systematic Review - Mark E Engel
• Molecular epidemiology of group A streptococcus (GAS) in north India - Rajesh Kumar
• Quantifying the age of first infection with skin sores in five remote Australian Aboriginal communities - Michael Lydeamore
• Epidemiology and antibiotic resistance of group A streptococci isolated from healthy schoolchildren in Rawalpindi, Pakistan.   - Irum Perveen